Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis

The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such as inducing cell proliferation, inhibition of apoptosis, and suppressing the host’s immune response. Furthermore, COX-2 can induce the production of vascular endothelial growth factors, hence, promoting angiogenesis. Indeed, the ability of COX-2 inhibitors to selectively restrict the proliferation of tumor cells and mediating apoptosis provides promising therapeutic targets for cancer patients. Thus, in this comprehensive review, we summarized the reported differential expression patterns of COX-2 in different stages of head and neck carcinogenesis—from potentially premalignant lesions to invasive carcinomas. Furthermore, we examined the available meta-analysis evidence for COX-2 role in the carcinogenesis of HNC. Finally, further understanding of the biological processes of COX-2 and its role in orchestrating cell proliferation, apoptosis, and angiogenesis may give therapeutically beneficial insight to develop the management plan of HNC patients and improve their clinical outcomes.     

Differences between oculomotor and perceptual artifacts for temporally limited head mounted displays

We used perceptual and oculomotor measures to understand the negative impacts of low (phantom array) and high (motion blur) duty cycles with a high‐speed, AR‐likehead‐mounted display prototype. We observed large intersubject variability for the detection of phantom array artifacts but a highly consistent and systematic effect on saccadic eye movement targeting during low duty cycle presentations. This adverse effect on saccade endpoints was also related to an increased error rate in a perceptual discrimination task, showing a direct effect of display duty cycle on the perceptual quality. For high duty cycles, the probability of detecting motion blur increased during head movements, and this effect was elevated at lower refresh rates. We did not find an impact of the temporal display characteristics on compensatory eye movements during head motion (e.g., VOR). Together, our results allow us to quantify the tradeoff of different negative spatiotemporal impacts of user movements and make subsequent recommendations for optimized temporal HMD parameters.     

主/次显示器视距设计对头部关节舒适度的影响

以视平线可与显示器中心重合为准,分别探讨显示器中心在视平线上方、下方时不同视距对头部关节舒适度的影响. 实验自变量为视距(眼睛与显示器中心的水平距离),因变量为头部关节舒适度. 实验结果显示:1)显示器中心在人视平线上方时,头部舒适性状态始终处于不舒适状态,此时视距与人的头部舒适性关系成正比,即视距越大,头部舒适性越好;2)显示器中心在人视平线下方时,头部关节舒适状态始终处于正常范围,舒适性程度随视距增大而减小.     

石化装置蒸汽发生系统的仪表工程设计

主要探讨了某石化装置蒸汽发生系统的仪表工程设计，提出了复杂控制方案、联锁方案设计，同时也详述了影响系统设计的因素，如测量补偿和迁移等。     

折边锥形封头厚度计算探讨

分析了GB 150-1998《钢制压力容器》中圆筒和折边锥形封头大端的厚度计算公式,认为计算折边锥形封头的厚度时,可只考虑与过渡段相接处的锥壳厚度。     

带像差补偿的光盘像散自动调焦透镜设计

对光盘光学头检测光路中广泛使用的光学平板所引入的光学像差进行分析计算,并由 此设计了一种放置于光盘光学头检测光路中的用以产生聚焦误差信号的像散透镜。它不但可以产生正常的调焦误差信号,同时还可以补偿由斜放入检测光路中的光学平板所带来的光学像差。经过实际应用,证明这种结构完全能够满足高密度光盘光学头的技术要求。     

一个计算机动画转头模型

本文提出一个用于计算机动画的转头模型。它利用头部的正面和侧面形象来构造出头的三维结构形象，然后按指定的旋转轴旋转该结构，经过边缘轮廓提取及隐线消除，最终得到正确的转头过程序列画面。     

有水气藏开发早期可采储量的评价方法

有水气藏是天然气藏中的一个基本气藏类型，其采收率受多种因素的影响，如地面集输压力、井筒混合气水流动的液柱压力和储层物性等，目前普遍采用经验取值、物质平衡和气藏数值模拟等方法进行研究，但由于受开发评价阶段试采资料偏少和气藏数值模拟无法模拟井筒流动等因素的影响，早期采收率计算往往偏差较大，针对这些问题，从气田开发一体化的特点出发，提出了一种全面考虑地层→井筒→地面流动条件下，有水气藏（含凝析有水气藏）发废弃压力的计算方法，发展了利用物质平衡早期预测有水气藏采收率的理论，方法可靠、适用性强，能够推广应用。     

深孔钻机水刹车传动机构的设计改进

针对深孔钻机水刹车传动机构原设计结构中存在的问题进行分析、研究、并对机构进行了改进，满足了钻机绞车的各项性能指标和技术要求。     

轧机主传动万向联轴器辊端接头结构探讨

分析了衬板槽平面与叉头十字轴孔轴线的相对位置对辊端接头应力的影响 ,研究了轧辊扁头与衬板之间间隙所产生的冲击和应力集中 ,讨论了辊端接头中部过渡段结构对应力分布和制造质量的影响。提出辊端接头结构设计的优化方案